Quantitative analysis of electroencephalography (EEG) is used increasingly to evaluate the
pharmacodynamics of benzodiazepines. The present study aimed to apply the EEG method
as well as more traditional approaches to an interaction study of bromazepam and
fluconazole. Twelve healthy male volunteers participated in a randomized, double‐blind,
four‐way crossover study. The subjects received single oral or rectal doses of bromazepam
(3 mg) after 4‐day pretreatment of oral fluconazole (100 mg daily) or its placebo. Plasma …

CiNii 博士論文 - Effect of fluconazole on the pharmacokinetics and pharmacodynamics of
oral and rectal bromazepam : an application of electroencephalography as the
pharmacodynamic method … Effect of fluconazole on the pharmacokinetics and
pharmacodynamics of oral and rectal bromazepam : an application of
electroencephalography as the pharmacodynamic method ブロマゼパム経口及び経直腸
投与後の薬物動態及び薬効に及ぼすフルコナゾールの影響 : 薬力学的評価としての脳波の応用 …